Cardioversion and Digitalis

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Cardioversion and Digitalis

CARDIOVERSION has proved an effective and safe method for reverting ectopic arrhythmias to sinus rhythm.1'-" However, there is increasing evidence that capacitor electrical discharge may provoke arrhythmias in experimental animals12"-4 as well as in man.2' 6, 15 The majority of abnormal rhythms immediately following cardioversion are atrial in origin and are not serious. They generally represen...

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Cardioversion and digitalis. IV. Effect of beta adrenergic blockade.

Experiments were performed in anesthetized dogs to study some effects of propranolol, dextro-propranolol and ICI50,172 on digitalis-induced arrhythmias and digitalis-induced sensitization to electrical shock. When given in beta-blocking doses, propranolol did not abbreviate ouabain-induced ventricular tachycardia (VT) or decrease ouabain-induced sensitization to electrical shock. In larger dose...

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Cardioversion and digitalis drugs: changed threshold to electric shock in digitalized animals.

• Cardioversion is now widely accepted as the method of choice for terminating a number of atrial, nodal and ventricular arrhythmias." The technique consists of administering from a capacitor a specific underdamped monophasic electrical pulse across the intact chest. When the heart is exposed to electrical energy, there is a risk of producing ventricular fibrillation. With this new technique, s...

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Diphenylhydantoin prevention of arrhythmias in the digitalis-sensitized dog after direct-current cardioversion.

an average of 155 watt-seconds was required to produce ventricular tachycardia. Immediately after recovery from digitalis toxicity, an average of 23 watt-seconds produced ventricular tachycardia. The administration of diphenylhydantoin at this time immediately increased the threshold required for ventricular tachycardia to an average of 363 watt-seconds. In eight studies, diphenylhydantoin was ...

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Digitalis.

Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in his late 18th century monograph on the efficacy of the leaves of the common foxglove plant (Digitalis purpurea). Despite their widespread acceptance into medical practice in the ensuing 200 years, both the efficacy and the safety of this class of drugs continu...

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ژورنال

عنوان ژورنال: Circulation

سال: 1966

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.33.6.878